This may result in a loss of therapeutic activity. Pular no carrossel. Anterior no carrossel. Enviado por Ark Olfato Parojinog. Denunciar este documento. Pesquisar no documento. Julia Bottini. Joel Gray. Sagar Modasiya. SirWin Amid. Gede Siddiarta. Dean Mercado. Damian ezequiel Benito. Steven Lau. Atthapu Thirupathaiah. Ire Reign Francisquite. Devansh Hitiksha Bhatt. A Ali. Sayedad Hossain. Christabel Vijitha. Vignesh Vicky. Pothik Ochena. OKP for the preparation of Sulphuric acid 0.
Mais de Ark Olfato Parojinog. Angel Camallere. Ark Olfato Parojinog. Walter Nelson. This can also lead to altered cellular drug transport.
Examples: 1. Tetracycline interacts with milk forming unabsorbed complex altered absorption. Antibiotics kill large number of normal flora of intestine, thus drugs like digoxin when given with antibiotics, toxicity appears due to altered metabolism of digoxin. Sulphonamide displaces warfarin thus leading to bleeding altered distribution. Penicillin and tetracycline are weak acid and are unionized in acidic pH thus are reabsorbed in the body altered excretion 5.
Caffeine oral increases and chloral hydrate oral decreases sedation and drowsiness, thus two should not be prescribed together.
Physical Incompatibility Physical incompatibility is the result of interaction between two or more substances which lead to change in color, odor, taste, viscosity and morphology. It can occur due to insolubility of prescribed agent in vehicle, immiscibility of two or more liquids or liquification of solids mixed in a dry state called eutexia. The solubility of the drug can be altered due to change in pH, milling, use of surfactant, chemical reaction, complex formation and co-solvent used.
Benzalkonium chloride and sodium lauryl sulfate when are mixed, a precipitate is formed because benzalkonium chloride is positive charged while sodium lauryl sulfate has negative charge. A prescription containing Ephedrine sulfate, menthol and liquid paraffin is incompatible due to ephedrine sulphate , a salt soluble in water not in organic solvents, oil and paraffin.
Immiscibility appears in emulsion, creams, lotions and ointments In can happen due to incomplete mixing, addition of surfactants, presence of microorganism or change in temperature. Liquefaction, a physical incompatibility occurs when two solid substances are mixed together, conversion to a liquid state takes place. The reasons for liquefaction are i When the solid substance is soluble in another solid substance, decrease of its melting point and conversion to a liquid take place.
Chemical Incompatibility Chemical incompatibility is a reaction between two or more substances which lead to change in chemical properties of drug or its pharmaceutical dosage form. It can occur due to oxidation, hydrolysis, polymerization, isomerization, decarboxylation, absorption of CO2, combination or formation of insoluble complexes.
Chemical incompatibility is of two types: Tolerated Chemical Incompatbility: The incompatability is minimized by changing the order of mixing not the components.
Adjusted Chemical Incompatability: Here addition or substitution of interacting component is done without affecting the efficacy. In sodium salicylate mixture, syrup of lemon is used as flavorant, it reacts with sodium salicylate, forming an insoluble salicylic acid, thus instead of syrup of lemon, tincture of lemon can be used.
Some other examples of such type of incompatibility include: Examples: 1. Phenylephrine shows change in color due to oxidation.
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